We give a comparison inequality that allows one to estimate the tail probabilities of sums of independent Banach space valued random variables in terms of those of independent identically distributed random variables. More precisely, let X1, . . . , Xn be independent Banach-valued random variables. Let I be a random variable independent of X1, . . . , Xn and uniformly distributed over {1, . . . , n}. Put ˜.

Lists of species underpin many fields of human endeavour, but there are currently no universally accepted principles for deciding which biological species should be accepted when there are alternative taxonomic treatments (and, by extension, which scientific names should be applied to those species). As improvements in information technology make it easier to communicate, access, and aggregate biodiversity information, there is a need for a framework that helps taxonomists and the users of taxonomy decide which taxa and names should be used (...) by society whilst continuing to encourage taxonomic research that leads to new species discoveries, new knowledge of species relationships, and the refinement of existing species concepts. Here, we present 10 principles that can underpin such a governance framework, namely (i) the species list must be based on science and free from nontaxonomic considerations and interference, (ii) governance of the species list must aim for community support and use, (iii) all decisions about list composition must be transparent, (iv) the governance of validated lists of species is separate from the governance of the names of taxa, (v) governance of lists of accepted species must not constrain academic freedom, (vi) the set of criteria considered sufficient to recognise species boundaries may appropriately vary between different taxonomic groups but should be consistent when possible, (vii) a global list must balance conflicting needs for currency and stability by having archived versions, (viii) contributors need appropriate recognition, (ix) list content should be traceable, and (x) a global listing process needs both to encompass global diversity and to accommodate local knowledge of that diversity. We conclude by outlining issues that must be resolved if such a system of taxonomic list governance and a unified list of accepted scientific names generated are to be universally adopted. (shrink)

Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin‐converting enzyme (ACE) is the central component of endocrine and local tissue renin–angiotensin systems (RAS), which also regulate diverse aspects of whole‐body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be regulated by mitochondrial UCPs. In genetic analysis of two unrelated populations (healthy young UK men and Scandinavian diabetic patients) serum ACE (sACE) activity was significantly higher amongst UCP3‐55C (rather than (...) T) and UCP2 I (rather than D) allele carriers. RNA interference against UCP2 in human umbilical vein endothelial cells reduced UCP2 mRNA sixfold (P < 0·01) whilst increasing ACE expression within a physiological range (<1·8‐fold at 48 h; P < 0·01). Our findings suggest novel hypotheses. Firstly, cellular feedback regulation may occur between UCPs and ACE. Secondly, cellular UCP regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism. This might partly explain the reduced risk of developing diabetes and metabolic syndrome with RAS antagonists and offer insight into the origins of cardiovascular disease in which UCPs and ACE both play a role. (shrink)

I Foundations i Every account of Nietzsche is an interpretation. Perhaps students of him are inclined to forget the extent to which this is also true of ...

Psychopaths continue to be demonised by the media and estimates suggest that a disturbing percentage of the population has psychopathic tendencies. This timely and controversial new book summarises what we already know about psychopathy and antisocial behavior and puts forward a new case for its cause - with far-reaching implications. Presents the scientific facts of psychopathy and antisocial behavior. Addresses key questions, such as: What is psychopathy? Are there psychopaths amongst us? What is wrong with psychopaths? Is psychopathy due to (...) nature or nurture? And can we treat psychopaths? Reveals the authors' ground-breaking research into whether an underlying abnormality in brain development leaves psychopaths with an inability to feel emotion or fear. The resulting theory could lead to early diagnosis and revolutionize the way society, the media and the state both views and contends with the psychopaths in our midst. (shrink)

Empathy is a lay term that is becoming increasingly viewed as a unitary function within the field of cognitive neuroscience. In this paper, a selective review of the empathy literature is provided. It is argued from this literature that empathy is not a unitary system but rather a loose collection of partially dissociable neurocognitive systems. In particular, three main divisions can be made: cognitive empathy , motor empathy, and emotional empathy. The two main psychiatric disorders associated with empathic dysfunction are (...) considered: autism and psychopathy. It is argued that individuals with autism show difficulties with cognitive and motor empathy but less clear difficulties with respect to emotional empathy. In contrast, individuals with psychopathy show clear difficulties with a specific form of emotional empathy but no indications of impairment with cognitive and motor empathy. (shrink)

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

_The Sceptics_ is the first comprehensive, up-to-date treatment of Greek scepticism, from the beginnings of epistemology with Xenophanes, to the final full development of Pyrrhonism as presented in the work of Sextus Empiricus. Tracing the evolution of scepticism from 500 B.C to A.D 200, this clear and rigorous analysis presents the arguments of the Greek sceptics in their historical context and provides an in-depth study of the various strands of the sceptical tradition.

We provide a justification for political liberalism’s Reciprocity Principle, which states that political decisions must be justified exclusively on the basis of considerations that all reasonable citizens can reasonably be expected to accept. The standard argument for the Reciprocity Principle grounds it in a requirement of respect for persons. We argue for a different, but compatible, justification: the Reciprocity Principle is justified because it makes possible a desirable kind of political community. The general endorsement of the Reciprocity Principle, we will (...) argue, helps realize joint political rule and relationships of civic friendship. The main obstacle to the realization of these values is the presence of reasonable disagreement about religious, moral, and philosophical issues characteristic of liberal societies. We show the Reciprocity Principle helps to overcome this obstacle. (shrink)

Philosophy &Public Affairs, Volume 47, Issue 1, Page 72-103, Winter 2019.

Political liberals ask citizens not to appeal to certain considerations, including religious and philosophical convictions, in political deliberation. We argue that political liberals must include a demanding requirement of intellectual modesty in their ideal of citizenship in order to motivate this deliberative restraint. The requirement calls on each citizen to believe that the best reasoners disagree about the considerations that she is barred from appealing to. Along the way, we clarify how requirements of intellectual modesty relate to moral reasons for (...) deliberative restraint. And we argue against attempts to weaken our requirement of intellectual modesty by emphasizing those moral reasons. (shrink)

In this paper I argue that human pattern recognition can be simulated by automata. In particular, I show that gestalt recognition and recognition of family resemblances are within the capabilities of sufficiently complex Turing machines. The argument rests on elementary facts of automata and computability theory which are used to explicate our preanalytic, informal concepts concerning gestalt patterns and recognition. The central idea is that of a machine which "knows" its own structure. Although the paper thus aims to support mechanism, (...) especially as a framework hypothesis for perception, it contains suggestions for philosophy of science and philosophy of language as well. Some of these suggestions are sketched in the final section. (shrink)

First published in 1992. Routledge is an imprint of Taylor & Francis, an informa company.

First published in 1992. Routledge is an imprint of Taylor & Francis, an informa company.

This study investigated the performance of boys with psychopathic tendencies and comparison boys, aged 9 to 17 years, on two tasks believed to be sensitive to amygdala and orbitofrontal cortex func- tioning. Fifty-one boys were divided into two groups according to the Psychopathy Screening Device (PSD, P. J. Frick & R. D. Hare, in press) and presented with two tasks. The tasks were the gambling task (A. Bechara, A. R. Damasio, H. Damasio, & S. W. Anderson, 1994) and the Intradimensional/ (...) Extradimensional (ID/ED) shift task (R. Dias, T. W. Robbins, & A. C. Roberts, 1996). The boys with psychopathic tendencies showed impaired performance on the gambling task. However, there were no group differences on the ID/ED task either for response reversal or extradimensional set shifting. The implications of these results for models of psychopathy are discussed. (shrink)

In this chapter, Hankinson discusses the sceptical attacks on dogmatic accounts of cause and explanation, beginning with the Eight Modes of Aenesidemus, before moving on to discuss Sextus Empiricus’ general attack on the very coherence of the notions of causation. Aenesidemus’ Eight Modes are a set of arguments of varying scope and power against the Aetiology of the Dogmatists; they demonstrate the fundamental difficulties in any attempt to investigate the hidden structures of things, and also raise methodological difficulties. Sextus Empiricus (...) argues that the very concepts of cause and effect are incoherent, and he also criticizes the notions of agent and patient, and the dogmatist account of sign‐inference. Hankinson also discusses the Modes of Agrippa, according to which an explanation is either circular, infinitely regressive, or arbitrary. The sceptical attacks on astrology and divination are also important in that they undermine the claims of pseudo‐science; such arguments, Hankinson adds, contribute to the understanding of the standards towards which genuine science must strive. (shrink)

In the Archaic Geek world of epic poetry, the causes of things are shrouded in divine mystery; the gods intervene in human affairs, and bring about events, in a cruel and capricious fashion, according to their whims; Apollo visits the devastating plague of Iliad 1 on the Greek host to avenge Agamemnon's ill-treatment of one of his priests; Poseidon shakes the earth and angers the sea, bringing to destruction those who have incurred his ire, as does Zeus himself with his (...) thunderbolts. The gods take on human shape and intervene in battle with devastating effect. In tragedy, the houses of Atreus and of Laius are brought low when men offend against the gods. This article focuses on the explorations of the fundamental concepts of reasons and causation, and the problems of explanation, and argues that it is indeed reasonable to see in Presocratic thought the foundations of Western scientific explanation. (shrink)

This study investigates the ability of individuals with psychopathy to perform passive avoidance learning and whether this ability is modulated by level of reinforcement/punishment. Nineteen psychopathic and 21 comparison individuals, as defined by the Hare Psychopathy Checklist Revised (Hare, 1991), were given a passive avoidance task with a graded reinforcement schedule. Response to each rewarding number gained a point reward specific to that number (i.e., 1, 700, 1400 or 2000 points). Response to each punishing number lost a point punishment specific (...) to that number (i.e., the loss of 1, 700, 1400 or 2000 points). In line with predictions, individuals with psychopathy made more passive avoidance errors than the comparison individuals. In addition, while the performance of both groups was modulated by level of reward, only the performance of the comparison population was modulated by level of punishment. The results are interpreted with reference to a computational account of the emotional learning impairment in individuals with psychopathy. (shrink)

David Hume (1711–1776) believed a ‘confederacy of authors’, brought together by the notoriously pugnacious William Warburton (1698–1779), were his most consistent and scurrilous critics. Warburton and his ‘School’ were Hume’s bêtes noires and embodied so much of what he fought against. Only there is reason to believe that the ‘Warburtonian School’ was more a useful fiction than a historical reality. The following deep dive into Humeana and the ‘stuff of anecdote’ digs up substantial conclusions about Hume’s philosophical project and context. (...) Any glorifying picture of Hume admirably ignoring sustained ‘Warburtonian’ name-calling is not an accurate description of the early reception of his writings. Hume did respond – at least, occasionally, privately and publicly. Moreover, the ‘Warburtonian School’ does not seem to exist – at least, it did not exist if it is taken to refer to a coherent group of writers, numbering more than two, concerned with attacking Hume. The response to Hume of ‘Warburtonians’ who can be identified was varied, disparate, and often positive. Warburton even came to like Hume’s historical writings. Hume’s claim that such a School existed may have led to the post hoc creation of the School in the minds of late eighteenth- and nineteenth-century commentators. (shrink)

This is the ideal book for anyone interested in Nietzsche's life and work who wishes to learn why he is such a significant figure for the development of modern ...

This is the second volume in the new monograph series sponsored by the American Philosophical Quarterly and judging by the high quality of most of the essays in this collection the idea for such a series seems to be a good one. A wide variety of topics in contemporary philosophical logic are discussed in seven essays, as suggested by the following brief account of their contents: Montgomery Furth's "Two Types of Denotation" is a careful study of Frege's views of (...) denotation, function, and object which manages to make some original suggestions as well as to clear up some confusing features of Frege's discussion. Jaako Hintikka's "Language Games for Quantifiers" develops interesting connections between the uses of quantifiers and various verbs related to seeking and finding and with these connections in mind offers a game theoretic interpretation of quantifiers. J. W. Cornman's admirably clear essay "Types, Categories and Nonsense" discusses the views of Ryle, Russell, Black, Pap, and Sommers on categories and types, formulating criteria of type difference close to that of Sommers. In "A Theory of Conditionals," R. C. Stalnaker takes some clues from the semantical analysis of modal logics in order to present an analysis of 'if... then...' statements and to deal with some epistemological problems about counterfactuals. In "Goodman's Nominalism," A. Hausman and C. Echelberger discuss certain facts which, in their view, no nominalist ontology, including Goodman's can deal with. Ted Honderlich's "Truth: Austin, Strawson, Warnock" is a discussion of Austin's views on truth and some of the confusions surrounding commentary on and criticism of it. Honderlich suggests his own definition of truth in the article. Finally, Colwyn Williamson in "Propositions andPropositions" discusses the various arguments which have been put forward to show that propositions are entities of a sort distinct from sentences. He rejects all such arguments as well as their conclusion.--R. H. K. (shrink)